Saturday, January 23, 2010

Success rate in IVF

Success rate in IVF

In the IVF treatement, the level of response of the ovaries varies greatly when women take the injectable FSH drugs for ovarian stimulation . This leads to a range of eggs being retrieved at the egg retrieval procedure. Before we have stimulated the woman with the FSH containing drugs, antral follicle counts are the best predictor of the response that the ovaries will give, and the number of eggs that will be retrieved.

The main factors affecting IVF outcome include the following:

* Age of the woman ( and consequently, her ovarian reserve )
* Normalcy of the uterus, and semen quality
* Success or failure of fertilization and cleavage in vitro
* Number of embryos transferred and cryopreserved
* Adequacy of the luteal phase after transfer
* Individual Body response and lifestyle.
* Women that respond well to the drugs sometimes will also have better egg quality as well - which will be more likely to develop into quality embryos and better results.

What we ahve seen that Ratio of Success is as under mentioed graph wise.




This statistics may not be appled to an individual patient or couple within an age or treatment group. Success rates vary depending on many factors including the causes of infertility, the adequacy of ovarian reserve, as measured by cycle day - 3 serum FSH, LH, estradiol levels, and the clomiphene citrate challenge test, and the number of eggs, maturity, and quality of eggs retrieved.

In addition, success rates increase as the number of IVF stimulation attempts increase, probably ranging to a maximum of three to four stimulation cycles. Normally There are very less chaces in First attempt. In IVF its more of Body response study along with medication.


At Delhi IVF : Our goal is to help couples achieve their dreams of having children. We do not exclude couples due to the presence of factors that may negatively impact their success rates. In fact we take that as challenge and some time couple also doubt on us for failure. But that is part of our profession. We are happy for them and if they conceive and have a child, nothing is better then that. Some time female come at very high age like 37+where we have low body responce and They do not have normal range of FSH and many other factors.

Some time couple come after First Failure from some where else and so out first IVF is treated as Second. In most of these cased we have very good results.

As the value of all test are crucial for treatment planing, so some time couple also get test doen at various labs where results of test varies.So DELHI IVF suggest the best LABS in Delhi for the same and also offer In house facility for these tests.

So there is not a single factor that effect the Success rate. One should get the treatment done at one place only rather go various places for every IVF attempt. At Delhi IVF, Dr. Anoop Gupta has a very good success rate of 40-50% if you choose to have Multiple IVF/IVF ICSI cycle. In fact we also offer Egg donations and Surrogacy Treatment also, if one really opt for the same, then Success rate is much higher.

Saturday, January 16, 2010

Why choose India for IVF Treatment?

Why choose India for IVF Treatment?

DELHI IVF is Delhi's oldest Infertility center, More than 300 patients treated have been treated by Delhi IVF. Dr. Anoop Gupta of Delhi IVF has reached on many mile stones for Infertility treatment. He comments "Every person has right to have a child" and he will be happy to provide all available treatment and help to parents to make it happen.

Few facts about us:
# 1st test tube baby in 1994.
# First IVF-ICSI baby in 1998.
# 250 Surrogacy procedures till 2008
# First blastocyst baby in Delhi 1999.
# 4000 ART babies till Jan.2009
# 500 Pregnancies in post Menopausal females delivered till Jan 2009.
# 600 egg donation till 2009.

The cost of the IVF treatment is comparatively low in India as compared to USA and UK. As law also are very good and give some relaxation to patients to opt for India for treatment.

As IVF is a growing problem world wide and in India also its considerably increasing. In India the infertility cases will increase to double in size in next few year and that wll raise a infertility crises. Although the cost if Infertility treatment is low in India but still out of reach for poor people of India. And due to this more and more IVF center are now coming up. AS Delhi is center of India, its the most preferred location for treatment. Dr. Anoop Gupta of Delhi IVF clinic speak about Infertility as part of life and take it as challenge to cure for everybody.

As many Fertility clinics in UK, Israel, USA are facing big problem in providing Egg donars and also the Surrogate mother for Infertility treatment. In fact these option are very costly there. They also have many restriction by law. India is a obvious choice for Infertility treatment as here the cost os treatment, egg donor or Surrogate mother is far less then these places.

Many infertile couples want to come to Delhi IVF from UK, USA, Israel for their IVF treatment because we are so much more cost effective than US clinics. Our IVF treatment start from the DAY 1 of their arrival and help them to manage it in such a way that they need not to take to much of leaves etc. We fix their treatment in such a way that they can easily can take the IVF treatment progress and even monitor the same.

For more info pls visit www.delhi-ivf.com

Tuesday, January 5, 2010

The reasons why some patients fail multiple IVF.

The reasons why some patients fail multiple IVF cycles could be very complex, and it may be difficult to find an answer despite extensive workups. In this article, I will discuss the most common reasons why embryos may not implant, the testing that can be done in an effort to find an answer, and some of the potential treatment options available
for what has been called “recurrent implantation failure”. In general, the underlying cause for IVF failure can be attributed to problems with the embryos, the uterine environment, or the patient’s immune system.

As women get older, the quality of their eggs declines and the resulting embryos are more likely to have chromosomal abnormalities. Embryos that don’t carry a normal chromosomal component are likely to be lost soon after implantation or do not implant at all.

A thickening of the zona pellucida (the egg shell) can occur in some patients associated with advanced age, high FSH, or recurrent implantation failure. For those patients, the embryologist in the lab can create a small opening in the egg shell utilizing a technique called assisted hatching, which may help the embryo escape and implant. Using the same technique, skilled embryologists can also remove fragments (cellular debris between the cells) from “poor quality” embryos, improving their potential for implantation.

In some couples, the poor quality of the ir embryos can be also attributed to a male factor. Although the sperm contribution to embryonic development is generally more difficult to assess, a few tests are available that could help identify those cases of male factor with a low probability of achieving a successful outcome. There is some evidence
that high sperm DNA fragmentation is associated with reduced fertility potential, and it can be detected with the SCSA (sperm chromatin structure assay) or the SDD (sperm decondensation assay).

The immune system has been implicated in some cases of pregnancy failure, particularly for patients with recurrent pregnancy loss. Using the same logic, many investigators believe that a number of patients who fail to become pregnant after IVF are actually experiencing a very early loss due to immunological problems, before the pregnancy can be recognized. This topic still remains very controversial, as does the value of the different tests and the treatments advocated to treat the autoimmune disorders.

There are many more Biological Disorder or May be mixed effect of many problem. LIT (Lymphocyte Immunization Therapy) - Lymphocyte immune therapy is used in women with recurrent spontaneous abortions. Or some time IVF Failure also.